MINITRANSPLANTS: ALLOGENEIC STEM CELL TRANSPLANTATION WITH REDUCED TOXICITY
نویسندگان
چکیده
منابع مشابه
Minitransplants: allogeneic stem cell transplantation with reduced toxicity.
Allogeneic hematopoietic stem cell transplantation (HSCT) is used for the treatment of selected hematological malignancies. Its curative potential is based on two very different mechanisms, involving the conditioning regimen and the graft-versus-host reactions, respectively. The high-dose chemo-radiotherapy conditioning regimen is aimed at destroying tumor cells, ablating the host immune system...
متن کاملReduced-toxicity conditioning prior to allogeneic stem cell transplantation improves outcome in patients with myeloid malignancies.
The introduction of reduced intensity/toxicity conditioning regimens has allowed allogeneic hematopoietic cell transplantation to be performed in patients who were previously considered too old or otherwise unfit. Although it led to a reduction in non-relapse mortality, disease control remains a major challenge. We studied the outcome of 165 patients with acute myeloid leukemia (n=124) or myelo...
متن کاملTreosulfan and fludarabine: a new toxicity-reduced conditioning regimen for allogeneic hematopoietic stem cell transplantation.
New conditioning regimens are being explored to reduce toxicity and enable allogeneic bone marrow transplantation in patients not eligible for conventional transplantation. We have investigated treosulfan, an alkylating agent, with the aim of developing an efficient and reliable but less-toxic conditioning regimen. A series of 30 patients who were not eligible for standard conditioning therapy ...
متن کاملSTEM CELL TRANSPLANTATION Current update on reduced intensity regimens for allogeneic stem cell transplantation
Beside chemotherapy, immunotherapy represents an approach based on the more or less specific recognition of tumoral cells. Allogeneic stem cell transplantation (ASCT) has been used now for more than 3 decades in the treatment of malignant hemopathies. Several lines of evidence could show that donorderived immuno-competent effectors can exert a potent long lasting graft-versus-tumor activity. To...
متن کاملAllogeneic hematopoietic stem cell transplantation (HSCT) after reduced intensity conditioning.
Allogeneic hematopoietic stem cell transplantation (HSCT) following myeloablative (conventional) conditioning regimen is associated with a high incidence of transplant-related morbidity and mortality, limiting its use to younger patients without medical co-morbidities. Over the past few years, it has become more evident that the alloreactivity of transplanted donor immunocompetent cells against...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Acta Clinica Belgica
سال: 2003
ISSN: 1784-3286,2295-3337
DOI: 10.1179/acb.2003.58.1.005